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KMID : 0377619720230020201
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Korean Jungang Medical Journal
1972 Volume.23 No. 2 p.201 ~ p.207
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Influences of Manganese Chloride on the Succinylcholine Action to the Excised Organs
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金順泳/Kim, Soon Young
金聖淑/申庚澈/金俊一/Kim, Sung Sook/Shin, Kyung Chul/Kim, Joon Il
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Abstract
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Tyrode and Ringer solution contain MgCl2 as a component of those solution.
It has been well known that MgIt.activates ATPase in the muscle and that a small amount of Mn* in the animal body affects on the growth and reproduction.
Mn* also activates the ATPase two third as well as Mg* in the microsomal fraction of cardiac muscle.
The authors attempted to investigate the influences of manganese chloride, instead of magnesium chloride as a component of Tyrode and Ringer solution, to the effects of succinylcholine on the excised organs such as the atria of rabbits, intestine of rats and muscle-nerve preparation of frog´s gastrocnemius muscle.
The results obtained were as follows;
1. The effect of succinylcholine on the excised atria of rabbits in the normal Tyrode solution tended to be inhibited in the Tyrode solution which contained more than 0.3 mM manganese chloride. However, the effect of succinylcholine in the Tyrode solution which contained less than 0.3 mM manganese chloride was similar to that in normal Tyrode solution.
2. The increased activity of succinylcholine on the excised intestine of rats in the normal Tyrode solution was not so changed by the replacement of MgCl2 to MnC12 in the solution.
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